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KMID : 1134820120410091253
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Journal of the Korean Society of Food Science and Nutrition
2012 Volume.41 No. 9 p.1253 ~ p.1258
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Rubus coreanus Miquel Improves on Impairment of Memory in Senescence-Accelerated Mouse (SAM)
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Choi Mi-Ran
Lee Min-Young
Kim Jeong-Eun
Hong Ji-Eun
Jang Kuen-Hye
Lee Jae-Yong
Chun Jang-Woo
Kim Tae-Hwan
Shin Hyun-Kyung
Kim Eun-Ji
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Abstract
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In the present study, we investigated the effects of Rubus coreanus Miquel (RCM) on memory ability of senescence-accelerated mice (SAM). Prone 8 strains of SAM mice (SAMP8), which is a useful animal for investigating the mechanism of brain aging and senile dementia, were fed a diet containing 100 mg/kg body weight/day of RCM for 8 weeks. Memory ability of mice was examined by using passive avoidance test and Morris water maze test. SAMP8 mice showed remarkable memory impairment compared with senescence-resistant 1 strains of SAM (SAMR1). RCM significantly improved memory ability of SAMP8 mice. In addition, acetylcholineasterase activities decreased in the brain of SAMP8 mice treated with RCM. Taken together, these results suggest that RCM may act as an acetylcholineasterase inhibitor, thereby improving senescence-related memory impairment.
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KEYWORD
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Rubus coreanus Miquel, senescence-accelerated mouse, memory, passive avoidance test, Morris water maze test
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